The individual, whose name was not released for privacy reasons, did not develop Ebola symptoms during 21 days of monitoring at Nebraska Medical Center in Omaha, Nebraska, the center said in a statement.
Symptoms such as fever and abdominal pain may appear up to three weeks after contact with the virus, according to the U.S. Centers for Disease Control and Prevention.
The healthcare worker arrived for monitoring in Omaha on Dec. 29.
Officials said the individual left the city on Jan. 12.
If symptoms had developed, the medic would have been moved to the Nebraska Biocontainment Unit, one of only a few in the United States for treating highly infectious and dangerous diseases.
The Ebola outbreak in Democratic Republic of Congo is the second worst ever and has killed 385 of the 630 people likely infected since it began six months ago, according to the World Health Organization.
By Letitia Stein
U.S. Medic Declared Ebola-Free, Leaves Nebraska Quarantine